Archive For The “Israeli Medicine” Category
When we hear of new artificial intelligence (AI) applications, especially those that seem a bit too “big brother” for the liking of many, this story should better represent the true intent of libertarian paternalism, or the ethical framework designed to provide optimal decision making while still allowing for freedom of choice.
Medasense Biometrics, a company that has developed a patented technology platform to objectively assess the physiological response to pain (nociception), and which could ebb opioid addiction post-surgery.
See featured article on artificial intelligence.
This company has come up with a portable pain sensor that can tell doctors how much pain a patient is feeling and how much pain care they need. Using artificial intelligence algorithms and real-time data, the company’s easy-to-use system is already changing precision medicine, allowing for personalized and optimized pain care to ensure that the patient doesn’t get too many opioids.
“Unlike other aspects of anesthesia, there have not been good monitors of painful stimuli during surgery, and how patients react. It has thus been challenging for anesthesiologists to know how much medication is needed to blunt surgical pain in individual patients. The problem is that too much or too little pain medication (usually narcotics) can be harmful. A monitor that accurately measures how patients react to surgical pain might therefore help guide clinical care,” Dr. Daniel Sessler, the founder and director of the Outcomes Research Consortium (the world’s largest clinical anesthesia research group), tells NoCamels.
Indeed, the average rate of later opioid dependence and addiction among surgical patients hovers at 12 percent, according to a US national pain report.
“We know that the first exposure to opioids for a large number of people addicted to opioids occurs after surgery. Thus it is logical that if we have a technology that allows us to titrate opioids more carefully during surgery, we can potentially decrease the habituation to opioid analgesia that the body develops during and immediately after surgery,” Dr. Frank J. Overdyk, an anesthesiologist in Charleston, South Carolina, tells NoCamels in an email exchange.
In fact, a recent study published in a peer-reviewed American Society of Anesthesiologists journal showed a 30-percent reduction in remifentanil consumption (a potent, short-acting synthetic opioid analgesic drug that is given to patients during surgery to relieve pain and as an adjunct to an anesthetic) in procedures performed with the Israeli company’s platform.
The pain sensor tech has been part of a number of clinical studies across the world including in the US, Europe, Canada, Japan, Israel, and Chile.
“For the first time in the history of surgery and anesthesia will we have the ability to measure painful stimuli during surgery directly. Currently, we have had to use indirect measures of pain such as high heart rate, pupil dilation and sweating as signs of pain. The NOL will allow us to titrate pain medicines more precisely and early studies suggest we will be able to use less opioid pain medicine. For patients, this means fewer side effects such as nausea, vomiting, itching, constipation and inability to void,” says Overdyk.
How smiley-faces warned of the need for new pain assessment
Founder and CEO of Medasense, Galit Zuckerman-Stark grew up in operating rooms, watching her mom, a nurse, care for patients.
Just when we thought that the only absolute things in life are “death and taxes,” medical and scientific breakthroughs may be able to forestall the former indefinitely. Of course, we’re not there yet but not long from now it’s not hard to imagine the swapping out of vital organs much like car parts are replaced with factory new ones all the time.
And just like that, the Ship of Theseus thought experiment becomes remarkably relevant. In the metaphysics of identity, the ship of Theseus is a thought experiment that raises the question of whether a ship—standing for an object in general—that has had all of its components replaced remains fundamentally the same object.
All other things being equal, especially the presumption that our empirical history is retained by our brain (or a replacement… is that even possible?), we would still be the continuous meat package for this single irreducible component.
But enough of my meanderings. The excerpts that follow were originally reported by NoCamels.com, my “go to” resource for Israeli tech and innovation news.
The future is here. In a world first, Israeli scientists have created a live heart in a revolutionary new 3D printing process that combines human tissue taken from a patient.
In November, Tel Aviv University researchers said they invented the first fully personalized tissue implant engineered from a patient’s own biomaterials and cells, paving the way for new technology that would make it possible to develop any kind of tissue implant from one small fatty tissue biopsy.
Now, these same researchers created a real heart using their innovative process at the Laboratory for Tissue Engineering and Regenerative Medicine led by Professor Tal Dvir, an associate professor at Tel Aviv University’s Department of Molecular Microbiology and Biotechnology.
“This is the first time anyone anywhere has successfully engineered and printed an entire heart complete with cells, blood vessels, ventriclesProfessor Dvir, Tel Aviv University’s Department of Molecular Microbiology and Biotechnology
The process involved taking fatty tissue, after which the cellular and a-cellular materials were then separated. While the cells were reprogrammed to become pluripotent stem cells and efficiently differentiated to cardiac or endothelial cells, the extracellular matrix (ECM), a three-dimensional network of extracellular macromolecules, such as collagen and glycoproteins, were processed into a personalized hydrogel that served as the printing “ink,” Tel Aviv University said in a statement.
The differentiated cells were then mixed with the bio-inks and were used to 3D-print patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire, tiny heart.
Cardiovascular diseases are the number one cause of death worldwide, according to the World Health Organization. In 2016 alone, an estimated 17.9 million people died from heart diseases, a majority due to heart attack and stroke.
Heart transplantation is currently the only treatment available to patients with end-stage heart failure. And with a shortage of heart donors, this scientific breakthrough development may blaze a trail in the medical world, paving the way for a potential revolution in organ and tissue transplantation.
“This heart is made from human cells and patient-specific biological materials. In our process, these materials serve as the bioinks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models,” Professor Dvir said.
“People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future,” he added.
Tel Aviv University explained that in the current method for tissue engineering for regenerative medicine, cells are isolated from the patient and cultured in biomaterials, synthetic or natural, derived from plants or animals, to assemble into a functional tissue. After transplantation, they may induce an immune response that can lead to rejection of the implanted tissue.
Patients who are recipients of engineered tissues or other implants often require treatment with immuno-suppressors, which can endanger the health of the patient.
With this development, “patients will no longer have to wait for transplants or take medications to prevent their rejection. Instead, the needed organs will be printed, fully personalized for every patient,” the university said in a statement.
Featured article. Artificial Intelligence Disrupts MedTech Radiology.
The process was outlined in an article titled “3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts” published on Monday in “Advanced Science,” a peer-reviewed scientific journal.
Research for the study was conducted jointly by Professor Dvir, Dr. Assaf Shapira of TAU’s Faculty of Life Sciences, and Nadav Moor, a doctoral student in the lab.
In their study, the team worked with two models: one made from human tissue, and another made from rat tissue.
In the press briefing, Professor Dvir emphasized that the technology “won’t be available in clinics or hospitals tomorrow, we are in the very early stages of this technology.” But, he said, in about a decade, as 3D printing technology evolves, hospitals and clinics may have these printers on site.
Professor Dvir explained that the heart, currently the size of that of a rabbit’s, will need to undergo a maturing process in bioreactors – a system that supports a biologically active environment – to keep the cells alive and grow them to accommodate a life-sized heart, while “teaching” them to organize and interact with each other and achieve pumping ability.
Currently, he said, “the cells are capable of contracting separately but not pumping.”
The printing process takes between 3-4 hours, but the maturing process takes about a month, after which the scientists will begin testing on small animals such as rabbits and rats.
They hope this will happen in a year or two.
Dr. Shapira tells NoCamels that the scientists will 3D-print hearts for these respective animals from their own tissues after which they will conduct transplants and begin clinical trials.
The potential is great. According to Professor Dvir, the use of “native” patient-specific materials is crucial to successfully engineering tissues and organs.
“The biocompatibility of engineered materials is crucial to eliminating the risk of implant rejection, which jeopardizes the success of such treatments,” he said. “Ideally, the biomaterial should possess the same biochemical, mechanical and topographical properties of the patient’s own tissues. Here, we can report a simple approach to 3D-print thick, vascularized and perfusable cardiac tissues that completely match the immunological, cellular, biochemical and anatomical properties of the patient.”
But there are also significant hurdles. First is cost. Professor Dvir says the printing process for the heart cost “a few thousand shekels” in a lab environment, but should the technology be commercialized in the future, it will likely be expensive.
The scientists will have to print a human-sized heart and that could pose a challenge. “How do you print all the cells and blood vessels for a heart?” asked Professor Dvir in reference to the resolution limitations currently of 3D printers.
“We must take into consideration that 3D printing technology is also developing,” he said.
“Maybe, in 10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely,” he said.
Over a thousand visitors from forty-five countries converged on Tel Aviv for CannaTech, the medical Cannabis (marijuana) conference. Participants from the biotech, pharmaceutical, and medicine were all ears (and eyes) at what appears to be the world’s largest medical cannabis conference, giving Israel yet another designation of Cannabis Nation.
The following content has been exported from NoCamels.com where this story was originally reported.
According to Kaye, the Israeli government’s inhibition of cannabis business in the past, which he says was due to fear of the negative image associated with exporting “guns, cannabis, and other drugs,” made medical cannabis a “heavily illegitimate market.” Despite earlier government backlash, however, continuous pressure and a greater number of resources devoted to medical cannabis research have allowed for CannaTech’s consistent growth since its inception in 2015.
As perhaps the chief representative of the Israeli medical cannabis market, CannaTech’s development signifies Israel’s quick emergence as a global industry leader.
“We’re uniquely placed in innovation, ag-tech, water tech, and now canna-tech in order to propel us into what is the next massive industry […] When you add in the culture of funding startups, and the ability to both black market test and sell your product to an audience, that creates an environment that’s fantastic for a growing ecosystem,” Kaye states.
He also cites Israel’s advanced hospitals, universities and claim to the highest number of PHDs per capita as additional contributors to the country’s potential for sustained success in the industry and the world’s primary innovator and producer of medical cannabis.
“Patients who need medicine now have to get it from somewhere – they can get it from Canada or they can get it from Israel. Those are your options in the world. Canada’s leading and Israel will catch up.”
In January, Israel’s Ministry of Health gave its long-awaited approval for the medical cannabis export law, paving the way for the country to become a leading medical cannabis exporter, and participant in the global cannabis sector. Although law enforcement officials have not yet established a framework through which new international cannabis trade will be executed, the market has already begun to feel the law’s effects. “We are talking about a $2 billion industry next year that, last year, was also a $2 billion industry, it just wasn’t legal,” Kaye says.
By 2029, the global cannabis industry is expected to soar to $33 billion, which Kaye believes is necessarily an underestimate: “It’s the fastest growing industry in the world with more consumers than we know about because they have all been in the closet. So, we don’t really know the size, but it’s way bigger than whatever we think it’s going to be.”
Despite the growing support for medical cannabis within Israel and beyond, there are those who still doubt the plant’s positive potential, arguing that it may decrease societal productivity. Kaye urges doubters to reject “uneducated stigma that they’ve been taught for 60 years” and to instead, turn to cannabis research.
A new technological breakthrough is using AI and facial analysis to make it easier to diagnose genetic disorders. DeepGestalt is a deep learning technology created by a team of Israeli and American researchers and computer scientists for the FDNA company based in Boston. The company specializes in building AI-based, next-generation phenotyping (NGP) technologies to “capture, structure and analyze complex human physiological data to produce actionable genomic insights.”
Portions of this article were originally reported in NoCamels.com
DeepGestalt uses novel facial analysis to study photographs of faces and help doctors narrow down the possibilities. While some genetic disorders are easy to diagnose based on facial features, with over 7,000 distinct rare diseases affecting some 350 million people globally, according to the World Health Organization, it can also take years – and dozens of doctor’s appointments – to identify a syndrome.
“With today’s workflow, it can mean about six years for a diagnosis. If you have data in the first year, you can improve a child’s life tremendously. It is very frustrating for a family not to know the diagnosis,” Yaron Gurovich, Chief Technology Officer at FDNA and an Israeli expert in computer vision, tells NoCamels. “Even if you don’t have a cure, to know what to expect, to know what you’re dealing with helps you manage tomorrow.”
DeepGestalt — a combination of the words ‘deep’ for deep learning and the German word ‘gestalt’ which is a pattern of physical phenomena — is a novel facial analysis framework that highlights the facial phenotypes of hundreds of diseases and genetic variations.
According to the Rare Disease Day organization, 1 in 20 people will live with a rare disease at some point in their life. And while this number is high, there is no cure for the majority of rare diseases and many go undiagnosed.
“For years, we’ve relied solely on the ability of medical professionals to identify genetically linked disease. We’ve finally reached a reality where this work can be augmented by AI, and we’re on track to continue developing leading AI frameworks using clinical notes, medical images, and video and voice recordings to further enhance phenotyping in the years to come,” Dekel Gelbman, CEO of FDNA, said in a statement.
DeepGestalt’s neural network is trained on a dataset of over 150,000 patients, curated through Face2Gene, a community-driven phenotyping platform. The researchers trained DeepGestalt on 17,000 images and watched as it correctly labeled more than 200 genetic syndromes.
In another test, the artificial intelligence technology sifted through another 502 photographs to identify potential genetic disorders.
DeepGestalt provided the correct answer 91 percent of the time.
Indeed, FDNA, a leader in artificial intelligence and precision medicine, in collaboration with a team of scientists and researchers, published a milestone study earlier this year, entitled “Identifying Facial Phenotypes of Genetic Disorders Using Deep Learning” in the peer-reviewed journal Nature Medicine.
Move over mindfulness meditation. Neuroscience is now beginning to map what’s going on inside your brain when you’re feeling good, and not-so-good, to help promote mental and emotional wellness. It’s a logical augmentation of mindfulness meditation which has become very popular recently although it’s been around for thousands of years.
The remainder of this post was originally reported by NoCamels.com
Brain researchers across the world are increasingly beginning to study the link between our body’s control center and emotional health. In recent years, neurological wellness (or neuro-wellness), an emerging field focused on emotional wellbeing, mood enhancements and innovation and technology, has also garnered attention.
“Because we’re living longer, our focus is starting to shift toward well-being,” Bill Gates wrote last month as part of a piece reflecting on technological breakthroughs for the MIT Technology Review. “I think the brilliant minds of the future will focus on more metaphysical questions: How do we make people happier? How do we create meaningful connections? How do we help everyone live a fulfilling life?”
Earlier this month, this question was one of the main focuses at the Fourth International BrainTech Conference in Tel Aviv, a two-day global meeting point for leading scientists, clinicians and entrepreneurs who engage in brain research and technology.
While the power of a positive mindset has been praised as key, there is emerging scientific backing for the thesis that mood is directly linked to the mental processes in our brain. Moshe Bar, director of the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University, presented a study that found that optimistic people show better cognitive work on associations, creativity, memory and a broader scope of attention than those with a more depressed outlook. People with a positive mindset, he indicated, are better able to foresee what’s coming next and to minimize perceived uncertainty. Thus, improving the mood of individuals can prompt our brain to activate processes that will make us feel well.
The brain’s powerful capacities are well documented, but can the mind heal the body? Neuroscientists Dr. Talma Hendler, of Tel Aviv University, and Dr. Asya Rolls, of the Technion, are currently collaborating on a study on brain-body interaction. Their initial findings have shown that activating a neural mechanism in our brain’s reward system may boost the immune system.
Can technology support us emotionally? More and more entrepreneurs recognize the potential of such evidence for transforming our mind and body. Products for emotional wellness are currently flooding the market. But can technology really support us emotionally?
“Yes,” says Nichol Bradford, executive director and co-founder of The Transformative Technology Lab (USA), who believes that we are standing at the threshold of a new era of human flourishing. “I think there is a great deal of range and possibility in using technology to teach us how to relate to the way we feel. Emotions and self-regulation are trainable and teachable skills,” she tells NoCamels.
According to Bradford, transformative technologies for well-being will not only address mental health and happiness, they are also entering the future of workplaces, improving emotional intelligence and social skills. Ultimately, they will lead to enhanced mental and emotional capacity.
Bradford calls this the “future of human possibilities” in which technology helps people develop their full potential. “The point is … to establish a new level of mental and emotional health.“
An example of this is TRIPP, a Los Angeles-based software company that developed a mood-on-demand platform powered by virtual reality. Like a combination of video games and meditation, “taking a ten-minute TRIPP” can puts users in a state of mindfulness by creating a deep immersive, brain-stimulating experience. CEO and co-founder Nanea Reeves believes that mental health is the market for VR. After launching their product for corporate wellness programs, the company’s goal is to enter the therapeutic market, where TRIPP could be used for treatments like addiction recovery, he tells NoCamels.
An Israeli product that has already been deployed in hundreds of clinics worldwide is Myndlift, a device for personalized neuro-therapies. When looking for ways to improve ADHD symptoms without medication, Myndlift CEO Aziz Kadan discovered the potential of neurofeedback. Combining a sensory headset with a training program, Myndlift responds to changing brainwave patterns and is able to change and balance brain activation. The devices were featured at the conference.
Meanwhile, NYX Technologies, a young Israeli neurotech startup, is developing a platform for sleep management and stress reduction. A headset reads a user’s brain patterns and adapts its function individually for falling asleep faster, getting into deeper sleep and waking up refreshed. Currently, the Haifa-based company is conducting beta tests.
Israeli Biotech company Bonus Biogroup has created
The following excerpts were first reported by NoCamels.com.
When Danny Yaakobson, an extreme sports enthusiast, suffered a serious leg injury following a car accident two years ago, he did not imagine he would become the world’s first patient to receive a lab-grown bone implant made from his own fat cells to replace a missing section of his shinbone, let alone take part in an Israman triathlon just a year following the surgery.
But that is exactly what happened. While traveling abroad in 2017, Yaakobson suffered a road accident and nearly lost his whole leg. The injury was serious and painful, he says, but his doctor told him about a clinical trial that would change the course of his life.
“The doctor said that there wasn’t much to lose anyway [in participating in the clinical trial], that the situation was not so good as it was,” Yaakobson explains in a video interview provided by Bonus BioGroup.
During the process, human fat tissue is extracted from the patient. Bonus BioGroup then separates the various types of cells and isolates the stem cells. The stem cells are removed and stimulated in a bioreactor, a special device that simulates the body’s environment and provides suitable conditions for bone generation. The fat cells are then grown in a lab until the tissue becomes solid, after which the hardened bone tissue is injected back into the patient’s body.
Bonus BioGroup CEO Dr. Shai Meretzki says in a video interview that “currently an autologous [cells or tissues obtained from the same individual] transplant is the gold standard for treating patients who lose bones for a wide variety of reasons. In order to perform the process you need to harvest the bone for one location within the body. Usually you cut from the femur and move it to the cut location, which is a very hard, expensive, painful and difficult process.”
“What we are offering instead is a completely new approach to patients who have lost their bones for the most disparate reasons, growing the old bone outside of the human body within a relatively short time,” Meretzki says.
The surgery to replace a missing 2 inches (5 centimeters) of
Israeli Medtech startup Zebra Medical brings artificial intelligence (AI) to automatically detect brain anomalies. It’s like the optical character recognition (OCR) used to recognize words or other symbols when scanning a document. That’s basically how
The following content was first reported by NoCamels.com
Israeli startup Zebra Medical Vision will begin deploying its revolutionary medical imaging AI solutions in one of Israel’s largest hospitals, Tel Aviv’s Ichilov, as well as with Clalit Health Services and Maccabi Healthcare Services – Israel’s largest and second-largest HMO, respectively. The three medical entities manage some 90 percent of patients in Israel, the company said in a statement.
Zebra Medical said it received government support through grants from the Israel Innovation Authority for these projects, but did not disclose financial details.
See related story on artificial intelligence.
The company, founded in 2014 by Eyal Toledano, Eyal Gura, and Elad Benjamin, uses AI to read medical scans and automatically detect anomalies. Through its innovative development and use of 11 different algorithms, Zebra Medical can identify visual symptoms for diseases such as breast cancer, osteoporosis, fatty liver, and conditions such as vertebral fractures, aneurysms, and brain bleeds.
At Ichilov, also known as the Tel Aviv Sourasky Medical Center, which runs Israel’s largest ER section, the technology will prioritize radiologists’ worklists by scanning entire queues and flagging those that need immediate attention, thereby allowing those with life-threatening issues to be attended to more quickly.
“Emergency room patients will have their cases prioritized by AI, and if a CT scan includes a brain bleed or if a chest x-ray contains an acute condition such as pneumothorax, the patient’s imaging scan will be prioritized and placed at the top of the radiologist’s list for review, leading to earlier initiation of treatment,”wrote Eyal Gura, Zebra Medical Vision’s co-founder and CEO, in a post announcing the partnerships.
Women who are members of the Maccabi HMO and patients of its private medical centers, meanwhile, may undergo their annual mammography exams where both expert radiologists and AI algorithms review the scans. This is in a bid to increase chances of any cancer detection earlier, and reduce unnecessary biopsies and risks of misdiagnoses.
“Traditional Computer Assisted Diagnosis (CAD) technologies failed in the past by exposing too many false positives and we are hopeful that AI can bring new insight to the process of the ‘second-reading’ of scans,” Gura wrote.
At the Clalit HMO, Zebra will apply its technology to detect early signs of osteoporosis and heart disease in patients and alert physicians who can then apply preventative treatments.
Gura explains that the benefits will also apply to caregivers, who can work more effectively and quickly to provide care, and to the state which can manage a better healthcare budget and
“Every patient with an undetected acute condition such as brain bleed, pneumothorax, or other undetected conditions such as breast cancer, ends up (in the best case scenario) with more days hospitalized, requiring more expensive treatments, with more working days lost and a greater lack of productivity for his or her surrounding family and direct contacts,”Gura wrote.
Gura said the company was “humbled by the opportunity” and remained
“committed to providing the best solutions to our local care providers”
“In 2020, the majority of the people around us, including our loved ones, will be impacted by the tools we are creating,” he said in the company statement. “There is nothing more satisfying than that for our team.”
The Israel Innovation Authority’s CEO Aharon Aharon said the government agency “believes digital health to be of imperative and strategic growth engine for the entire Israeli economy,” and that Zebra Medical Vision’s participation in the program “represents the flagship that will help[…] substantiate and promote digital health in Israel.”
Professor Ronni Gamzu, CEO of Tel Aviv Sourasky Medical Center, said: “As a global leading ER center, we put significant emphasis on being on the cutting edge in terms of technology solutions that will empower our team. We selected Zebra-Med’s AI solutions to help our team perform faster and better diagnostics and we are certain that hundreds of thousands of patients will benefit from this new technology.”
Zebra Medical has seven CE marks for its various algorithms and 510(k) FDA clearance for one of them. It has raised over $50 million in venture funding since it was established five years ago.
In 2017, Zebra Medical partnered with multinational tech giant Google to provide its algorithms on Google Cloud, so hospitals and medical professionals in the US can access the service for $1 per scan. The company says its data and research platform has already yielded AI imaging insights for millions of scans.
The award-winning company has also been recognized as particularly innovative by Business Insider, Forbes, and Fast Company.
The more marijuana is put under the microscope, the more benefits become evident. The latest comes from an Israeli study showing that marijuana reduces symptoms in children suffering from Autism
The remainder of this article was originally reported in NoCamels.com
A new Israeli scientific study has shown that the use of medical cannabis in children under 18 diagnosed with autism spectrum disorders (ASD) can relieve common symptoms such as seizures, disruptive behaviors, depression, and restlessness.
ASD is a range of neurological disorders that affect communication, behavior, and social skills, and for which there is no specific treatment. According to the World Health Organization, it affects 1 in 160 children worldwide and over the past three decades, there has been a 3-fold increase in the number of children diagnosed, according to the study. Interventions often focus on intensive behavioral therapies that require high levels of care.
The Israeli study was conducted by researchers from Ben-Gurion University of the Negev (BGU) and the Soroka University Medical Center, among them Professor Raphael Mechoulam, the renown organic chemist who in 1964 was the first to identify cannabis’ THC compound, the chemical known for causing a “high.” Mechoulam is credited with laying the foundation for scientific research on cannabis and its use in modern medicine.
In the new study, titled “Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy” and published in the scientific journal Nature…
researchers found that over 80 percent of the parents of the children in the study reported significant or moderate improvement in their child.
The treatment in the majority of the 188 child patients was based on cannabis oil containing 30 percent CBD (Cannabidiol, a non-psychoactive chemical produced by the cannabis plant) and 1.5 percent THC.
All the children in the study, ranging in age from under 5 to 18, were previously diagnosed with ASD by certified neurologist or psychiatrist, as required by Ministry of Health prior to the initiation of the cannabis-based treatment.
The patients were assessed before the cannabis oil treatment, after a month of treatment, and after six months of treatment.
After a month, with 179 patients, 58 patients (48.7 percent) reported significant improvement, 37 (31.1 percent) moderate improvement; 7 patients (5.9 percent) experienced side effects and 17 (14.3 percent) reported that the cannabis did not help them. The side effects they reported included sleepiness (1.6 percent), bad taste and smell of the oil (1.6 percent), restlessness (0.8 percent), reflux (0.8 percent) and lack of appetite (0.8 percent).
After six months, with 155 patients and 93 respondents to a follow-up questionnaire on the treatment, 30.1 percent reported significant improvement, 53.7 percent moderate improvement, 6.4 percent slight improvement, and 8.6 percent said that saw no change in their condition.
The patients also reported that after 6 months of treatment, their quality of life improved (66.8 percent) and 63.5 percent noted a more positive mood. There was also a marked improvement in the ability to dress and shower independent (42.9 percent) and sleep better (24.7 percent).
True. Good ole Aloe Vera does a great job for the occasional burn from a hot stove, or the many scrapes kids seem to attract. The natural bovine treatment of Colostrum also does a bang up job for all types of open wounds. But until now, severe burn victims had to undergo months (if not years) of painful bandage wraps.
The new wound care treatment has a few advantages over traditional wound treatment. For starters, the treatment never touches the wound which reduces infection. In addition, no bandages are needed. Anyone who has undergone large scale burns know all-too-well the pain and suffering of having their bandages applied and basically ripped off the skin on a daily basis.
The following content was originally reported by NoCamels.com
Israeli-developed laser technologies are also sought after to help reduce the devastating impact of scars in burn victims.
“This is one of the birthplaces of laser medicine. You have doctors here who think innovation, it’s in their blood. It is a very exciting environment to work in,” US-based Burn Advocates Network founder Samuel Davis, tells NoCamels.
Davis was in town this week for the inauguration of the Israel Pediatric Aesthetic and Reconstructive Laser Surgery Center of Excellence (I-PEARLS), which he founded to be part of the National Burn Center at Sheba Medical Center.
Prof. Josef Haik, the Director of Israel’s National Burn Center Intensive Care Unit at Sheba Medical Center, and Prof. Arie Orenstein, director of the Sheba Medical Center Department of Plastic and Reconstructive Surgery, worked closely with Davis to develop this first center in the Middle East focused on non-invasive methods to heal scars.
In Israel, burns are the most common injuries among children (and especially in winter), according to the Ministry of Health. In 2017, 3,286 children were treated for burn wounds at emergency wards and Terem clinics, according to the latest data by the Ministry of Health
“Laser treatments have been around for years but somehow kids with burn scars got left out of the focus. When you take innovative clinicians and you put them together with the latest equipment, good things happen,” says Davis, a philanthropist from New Jersey who is also the founder of Camp Sababa, Israel’s camp for pediatric burn survivors.
“Sheba has a tradition of bringing catastrophic burn cases from Greece, Syria, Africa, the Palestinian Authority areas and from all over the region. This will just increase and expand the ability of the doctors to accept patients and teach physicians and surgeons in foreign countries. It increases the capability of Sheba to do its mission,” says Davis. “The center is already training doctors from other countries and we’re laying the groundwork to export I-PEARLS techniques.”
Indeed, Israel’s name as an innovator in the burn treatment space is sought out, agrees Barak, of Nanomedic.
“Israel is a source of a lot of innovation. All the physicians and companies with whom we’ve been in touch appreciate the innovative approach we have here,” she says.
We originally reported on this cancer cure story a few weeks back. Subsequently, a lot of red flags started appearing about the AEBi (Accelerated Evolution Biotechnologies, Ltd), including:
- The cancer cure would be available from day one and the subject will be completely cancer free within a year.
- That AEBi offered no evidence for its claim, only that they did not have enough funding to produce peer-reviewed publications.
- laims to be able to cure all forms of cancer.
- A notable cancer research scientist reported in a Forbes that the AEBi claimed to attack cancer cells three at a time, which is strange since cancer cells themselves can’t do that.
The following excerpts were originally reported by NoCamels.com
The new development was picked up by numerous media publications in Israel and across the world. Meanwhile, AEBi offered no evidence of its findings and claimed not to have the funds to publish any in peer-reviewed scientific journals.
But the company says its developed treatment, MuTaTo (multi-target toxin), is a new, multi-pronged attack on cancer cells using peptides that showed “consistent and repeatable” results in the “first exploratory mice experiment, which inhibited human cancer cell growth and had no effect at all on healthy mice cells, in addition to several in-vitro trials,” the Jerusalem Post reported.
Dr. Victoria Forster, a cancer research scientist and postdoctoral fellow at The Hospital for Sick Children (SickKids) in Toronto, Canada, wrote in a Forbes piece that the first “red flag” for her was a claim by AEBi’s CEO Dr. Ilan Morad on what the treatment could achieve.
“Instead of attacking receptors one at a time, we attack receptors three at a time – not even cancer can mutate three receptors at the same time,” Morad had told the Jerusalem Post.
“This is categorically untrue,” wrote Forster. “Cancers can have anywhere from one to tens of thousands of DNA mutations in their genomes, many of these being the ‘receptors’ Morad vaguely refers to. A key principle of using multiple chemotherapy agents at once is to go after cancer cells by several different routes to reduce the chance that they will become resistant. Still, many cancers do become resistant to these treatment protocols, so Morad’s logic here is extremely shaky.”
Furthermore, the Israeli company’s claim that its treatment will work for all types of cancers is also a “huge red flag,” she said.
“There are broadly over 200 different types of cancer and within those, multiple other subtypes. For there to be one, universal ‘cancer cure’ that overcomes all of these differences is highly unlikely,” Forster charged.
An Australian cancer research scientist went a step further, accusing the company of “selling unicorns” and calling for it to be hung out “to dry for making such cruel and misleading claims.”
In reference to popular culture, cancer biologist Dr. Darren Saunders said
Dr. J. Leonard Lichtenfeld, the deputy chief medical officer for the national office of the American Cancer Society, wrote in a blog post titled “A Cure For Cancer? Not So Fast” that while the Israeli scientists “worked with an interesting approach to interfering with the ability of cancer cells to function,” they provided very limited information that has “not been published in the scientific literature where it would be subject to review, support and/or criticism from knowledgeable peers.”
He further noted that AEBi’s initial experiment on mice in clinical trials “is not a well-established program of experiments which could better define how this works—and may not work—as it moves from the laboratory bench to the clinic.”
“The gap from a successful mouse experiment to effective, beneficial application of exciting laboratory concepts to helping cancer patients at the bedside is, in fact, a long and treacherous journey, filled with unforeseen and unanticipated obstacles,” Lichtenfeld wrote, pouring cold water on the claim that the treatment would be available in a year.